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Blu-ray Development Releases World's First 3D Biovascular Printer

When the European inventor Charles Hull developed the first 3D printing machine in 1983, he might have a hard time thinking that 32 years later, this technology has developed into such a breathtaking situation.
When the European inventor Charles Hull developed the first 3D printing machine in 1983, he might expect that 32 years later, this technology has developed into such a breathtaking situation.

Looks like an antique black printer, small and precise dual nozzles in a special space on the rotating rod, using bio-ink print out the basis of life - blood vessels. For example, in Linfen abstract paintings, the whole body veins that originally constituted the body of our life are drawn into a work. the person who discussed this is from Sichuan Blue Ray Yingnuo Biotechnology Co., Ltd.

On October 25, Chengdu, Sichuan, Sichuan Blu-ray Yingnuo Biotechnology Co., Ltd., which is a wholly-owned subsidiary of Blu-ray Development, announced that the world’s first 3D bio-vascular printer was launched and the re-infection of human organs was possible. “The breakthrough significance lies in the fact that the 3D bio-printing technology system based on stem cells at Blu-ray Innolux has been fully developed, including the four core technology systems: medical imaging cloud platform, bio-ink, 3D bioprinter and post-printing processing system, and organ reconstruction in the future. It is possible.” Yang Lan, chairman of Blu-ray Development, said. Every reporter from Shangxi

"Scientists + entrepreneurs"

On October 25th, hundreds of “big coffees” gathered in Chengdu in areas such as biomedicine, health care, and smart manufacturing. At the scene of the Blue Innoon "3D Printing Vascular Project Breakthrough and Product Launch Conference", this exquisite printer is undoubtedly the focus of the audience. Different from the existing 3D bioprinters on the market, the 3D bio-vascular printer invented by Blu-ray Yingnuo can print blood vessels with unique hollow structures and multiple layers of different types of cells. This is a groundbreaking product in the world.

At the scene, the printer clearly demonstrated the moment of  the miracle: from endothelial cells to smooth muscle cells to fibroblasts, the bio-ink used in each layer is not the same, rich in different nutrients. Ingredients, through a layer of special condensing material on the printing bar, continuously infiltrate and nourish the printing process of each cell layer. In the environment of 0-4 degrees Celsius, 3D biometric printing blood vessels take shape; When the surrounding environment is gradually raised to room temperature, The condensate material is peeled off from the already-printed blood vessels; the printed blood vessels will also be placed in a nutrient solution environment and slowly become active until they can “naturally bind” to other organs and tissues. “Establishment of any organ is an indispensable element for delivering nutrients to organs. In conjunction with Blu-ray's 'bio-brick' technology and relying on the data model of the cloud platform, we have successfully achieved blood vessel regeneration with 3D bio-vascular printers. This is the basis for the construction of all artificial biological active organs. Blue Innolux has taken a solid step in the realization of organ regeneration." The Chinese Ministry of Organization's first batch of "Thousand People Project" national experts, academicians of the American Academy of Toxicology, international regeneration Chairman of the Alliance for Medical Research Applications and Regulations, Executive Chairman of the Biomedical 3D Printing Council of the 3D Printing Technology Industry Alliance, and Prof. Kang Yujian, Chief Scientist of Blu-ray Yinguo, introduced the conference.

Biosynsphere, this sounding obscure term is the heart of 3D bioprinting technology. The popular explanation is that this is a novel, precise, biomimetic stem cell culture system that combines "bio-ink" consisting of seed cells (stem cells, differentiated cells, etc.), growth factors, and nutrients. Layers of other materials are printed out of the product, printed and processed to form a physiologically functional tissue structure. “3D bioprinting is completely different from industrial 3D printing using raw materials such as titanium alloys, bioceramics, and polymers, such as printing dentures, prostheses, and even automobiles, houses, etc. The fundamental difference between them is activity. Printing is to print out products that contain cellular components and have biological activity," said Ren Dongchuan, chairman of Blu-ray Yingnuo.

When all eyes are focused on this subversive product, the founders behind it seem to be more worthy of attention. On the eve of the press conference, from October 19 to 23, Sichuan Blu-ray Yingnuo Biotechnology Co., Ltd. was the only company that was sponsored by the National Development and Reform Commission and held in the National Independent Innovation Demonstration Zone in Zhongguancun, Beijing. A company recommended by Chengdu Hi-tech Zone in Sichuan.

Why does the world's leading 3D bioprinting technology appear in Chengdu, China and Sichuan Blu-ray? It is undeniable that this is a common issue for all members of the conference. The answer to this question is that Blue Inno represents a new type of entrepreneurial innovation model. Its greatest feature is that the pioneering scientist Yang Xing of Blu-ray Development said: “After the Prime Minister issued a call for 'mass entrepreneurship innovation,' I was thinking, if it was a scientist, how would this group of entrepreneurs start their own business?” With the development of printing technology, Yang Hao creatively set up a new entrepreneurial model of "core technology + capital" and "scientist + entrepreneur", giving scientists equity, setting up a partnership mechanism, and providing entrepreneurial platforms for scientists. Professor Kang Yujian is the chief scientist and CEO of Blu-ray Yingnuo under this model.

According to the Blu-Ray Development Announcement, they have invested 215 million yuan for R&D and research team building. Blu-ray Yingnuo also established a partnership mechanism, and the core personnel of Blu-ray Yingnuo will increase the capital of the company. The total amount of capital increase will be 16.15 million yuan. Walking at the intersection of Xixin Avenue and Dikang Avenue in the high-tech West Zone, Chengdu, Sichuan, the signboard for the “3D Bioprinting Global Innovation Center” has been erected, and greater follow-on investment is under way. The world’s first 3D bioprinting innovation industry park “-” The main building of the “Blu-ray Optics Valley” has been capped and is currently undergoing interior installation, laboratory renovation and procurement of experimental equipment. It will be completed and put into use by the end of August 2016.

From complex to business

The "China Made 2025" issued by the State Council has also clearly pointed out that the realization of biological 3D printing, the induction of pluripotent stem cells and other new technology breakthroughs and applications. Su Xuejing, a research fellow at CITIC Jianshe, believes that the advantage of 3D bioprinting lies in its complex manufacturing and technical characteristics. It has a huge application value in the biomedical field with a strong demand for personalization and will face a market of hundreds of billions of dollars. Luo Jun, Secretary General of the 3D Printing Technology Industry Alliance in the world, stated at the conference that “3D printing is one of the solutions to the contradiction between the individual needs of the health industry and the scaled manufacturing. 3D bioprinting is improving the level of existing medical technology. For example, in terms of personalized medicine, there will be great achievements.” This view coincides with Professor Dai Kejun, an academician of the Chinese Academy of Engineering who attended the press conference. “The customization of 3D bioprinting is a boon for personalized treatment.”

In an interview later, Yang Lan stated that "3D printing technology is itself called the fourth industrial revolution. It is subversive. From the perspective of industrial applications, it is already a military, modern industry, modern manufacturing industry. The more mature technology used, like the Boeing 787 in the United States, 32 large parts all use 3D printing technology. I was very shocked after contact with Professor Kang, and at the same time looked at a lot of information on 3D biology and 3D printing, so we pay close attention to Time, rush to promote this matter."

As the chief scientist of Blu-ray Yingnuo, Prof. Kang Yujian devoted himself to dozens of studies in the field of regenerative medicine. In the six years since he returned from the United States in 2009, Kang Yujian has even participated in only four professional conferences, and the rest of his time has used his words. That is "cultivating talent." “Everybody says it is the fourth industrial revolution. Is it not? We have to wait until the future to comment. I don’t care that it’s the first revolution, but it really created new opportunities for us in all walks of life. There are many things that can be done to seize this opportunity.” Kang Yujian said when interviewed by reporters including “Daily Economic News”.

Yang Xiao and Kang Yujian’s acquaintance is that they are in desperation. As the largest real estate company in Southwest China, Yang Hao is often invited to participate in some government investment promotion and investment negotiation activities. At that time, Kang Yujian was selected as the first batch of national experts for the "Thousand Talents Program" by the Sichuan Provincial Government as a guest professor at the West China Hospital of Sichuan University. On the common platform, the two had several exchanges. Like all real estate companies are seeking transformation, Yang Hao is looking for new investment blue ocean.

Kang Yujian was also looking for breakthrough opportunities for his own research. In 2001, during his work at the University of Louisville in the United States, he participated in and helped the school successfully implement the world's first full-heart transplant. A total of 14 cases of this type of surgery were performed. However, each adult male with a price of up to 250,000 U.S. dollars and needs to weigh more than 150 pounds can bear the surgical requirements, and the operation is deeply troubled by cost, application range, and production process, and cannot be approved by the US FDA. With the advent of 3D printing technology, Kang Yujian also wanted to solve this problem with this method. He printed out the artificial heart and achieved the world's first successful 3D printed artificial heart replacement surgery on the pig. However, as a biologist, he knew that there were still problems that were not solved - because they had no biological activity and could not be solved. Vascular endothelialization, vascular blockage and other issues.

How can we combine the above two issues? As early as 1996 to 1997, Kang Yujian published two papers on transgenic mice in JBC and JCI, the most authoritative biological science magazines in the United States. It is well known that an embryonic stem cell can differentiate into different organs at different times and eventually become a complete person, but no one can clearly explain why it can produce different differentiation at different times. Kang Yujian conducted research on this. The concept of "stem cell + 3D printing = 3D bioprinting" was born. "So, in the past 15 years, I only did one thing - focusing on the field of regenerative medicine and stem cell research," Kang Yujian said at the press conference. With 15 years of accumulation and continuous research breakthroughs, he has pioneered the development of the "Biosynsphere" technology, which is used to replicate various microenvironments during embryonic development, which will enable stem cells to be precisely oriented and controlled in vitro. Making organ printing possible is the "key" for organ reconstruction.

With the key in hand, can you easily open the door from technology to products to commodities? At what time can we use such printed organs to repair the tissues and organs of each of us?

In this regard, Kang Yujian also gave his answer: "In my report, I have already said that it is a phased one. We can think of it this way. For example, the engine I made was for the rockets of heaven, but the rockets Not just the engine, there are so many other components, but although this engine I can not immediately launch the rocket, but can be made to run on the ground, it is not also useful.I can not be made into a rocket I have made aircraft also have Therefore, we must not always be staring at the moment when we must be a rocket. Even if we run on the ground, this technology will have its proper effect."

Kang Yujian also mentioned that “3D bioprinting technology can achieve such research breakthroughs, and we are willing to cooperate with those institutions that are eager to break through R&D bottlenecks, and help them achieve the transformation and development of scientific research results. Because they use 3D bio-printing and bio-bricks, they can directly Since human stem cells, their physiological and pathological conditions and response to drugs are the closest to the human body, far superior to the existing two-dimensional cell culture and animal experiments, so the development of new drugs, drug sensitivity screening, drug toxicity and safety Many aspects such as detection may be superior to existing research and detection systems, and the results are more bionic, accurate, safe, and effective.”

Obviously, from the success of subversive trials to the ultimate value-equalization of products, there is still a long way to go, even if it is still not clearly delineated by its commercial value, but in the eyes of Yang Hao, do this. All that matters first is the word "complex." "With the development of China's economy, people's demand for the great health field is very huge. What do we do in the big health? We are going to be a hospital or be a health care product. Based on this feeling and desire, We chose a lot of projects, and finally selected 3D creatures in the health field."

However, Yang Lan also revealed several major strategies for how to realize its commercial value. "Blu-ray development itself is a listed company. Real estate is also a very good company in the region. We have the ability and conditions to incubate, and we continue to support Blu-ray Yingnuo. At the same time, we also have a big, healthy, well-being capital. The whole set is a question of business model design.” Yang Lan pointed out that Blue Inno hopes to establish 3D bioprinting innovations with its four core technology systems: its original medical imaging cloud platform, bioink, bioprinter and post-printing processing system. Chain, and the world's major medical institutions, research institutes, etc. to jointly develop the development and application of 3D bio-printing technology, and thus produce an industry chain to meet the individual needs of health, and promote the development of large-scale health industry.

Capital assistance

On the scene of the press conference on that day, in addition to the academic staff of the medical community, there was also a mysterious guest who came from nowhere. He was a special trip to Chengdu to investigate the founder of Quantum Fund, a world-famous investor Rogers, of the Blu-ray Yingnuo 3D bioprinting project.

Rogers said in an interview with reporters, “3D bioprinting technology will not only have vital scientific value in the future, but also have corresponding market value. In the United States and global capital markets, 3D concepts, biomedical concepts, and smart manufacturing concepts have been It is a hot spot for investment, and 3D bioprinting covers many of the above disciplines, and its high-tech features and life science concepts will become the focus of future investment. It will revolutionize organizational engineering, regenerative medicine, and medical research.”

“My previous understanding of this technology was not very comprehensive, so I came from a curious attitude. When Chairman Yang told me about this matter a few days ago, I expressed great expectations.” At the scene, Rogers accepted  an interview with the media including "Daily Economic News", talking about using 3D printing technology to print blood vessels, Rogers said "unbelievable."

During the following lab visits, Rogers repeatedly observed the 3D bioprinter, medical imaging cloud platform, and 3D imaging system. He also discussed with Professor Kang Yujian on 3D bioprinting in medical research, regenerative medicine, and clinical applications. Application market prospects. "Some problems are still very sharp, but he also expressed his admiration for the achievements made by Chinese private enterprises in the field of high-tech research." Ren Dongchuan said.

"3D bioprinting technology will not only have vital scientific value in the future, but will also have corresponding market value. In the United States and global capital markets, the concepts of 3D concepts, biomedical concepts, and intelligent manufacturing have always been investment hot spots." On the scene of the "Mold breakthrough of the 3D printing blood vessel project and product launch conference", Rogers met with the audience through a video. He said in the video, 3D bioprinting covers more than one subject, and its high-tech features and life science concepts will surely  become a key investment in the future and it will revolutionize organizational engineering, regenerative medicine and medical research.

In addition, the medical imaging cloud platform is a pre-application market for 3D bioprinting. It can be derived from the 3D viewing system, enabling doctors and patients to interactively see the film, the inquiry system. The patient can upload his own 2D image data to the platform and turn it into a 3D image. This intuitively shows that the patient's lesions are convenient for the patient to understand the condition and reduce the difficulty of the doctor-patient communication. On this basis, the patient can select the doctor that suits him and carry out relevant diagnostic consultations. . It can also help hospitals upgrade their existing information systems.


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